The objective of this study was to examine the impact of IVUS-guided post-PCI optimization on the occurrence of target vessel failure (TVF) at a 2-year follow-up, in comparison to standard of care. The study was conducted after the FFR React trial, where intravascular ultrasound (IVUS) was utilized to guide PCI optimization in patients with post-PCI FFR <0.90. The results demonstrated that IVUS-guided optimization significantly improved post-PCI FFR and post-PCI IVUS parameter values. Although there was a trend towards lower rates of TVF, TVMI (target vessel myocardial infarction), and TVR (target vessel revascularization) favoring the IVUS-guided optimization group, these findings did not reach statistical significance.
Background: In the FFR REACT trial, IVUS-guided PCI optimization in patients with post-PCI FFR <0.90 significantly improved post-PCI FFR and post-PCI IVUS parameters. IVUS-guided PCI optimization in patients with post-PCI FFR <0.90 did not reduce target vessel failure (TVF) as compared to standard of care.
Aims: To investigate whether IVUS-guided post-PCI optimization in patients with post-PCI FFR <.90 as compared to standard of care reduces TVF at 2-year follow-up.
IVUS-guided PCI optimization in patients with post-PCI FFR <.90 did not significantly reduce TVF at 2-year follow-up as compared to standard of care.
